Characteristic of the uncontrolled hypertension course in patients of the aral sea region with uncomplicated hypertensive crisis

Abstract Purpose To study the features of course uncontrolled arterial hypertension (AH) in Aral Sea region with identification prevalence various genotypes angiotensinogen (AGT) gene patients uncomplicated hypertensive crisis. Methods The genetic part included 94 crisis, an average age 55.3±8.6 years, 54 (58.3%)women and 40 men (41.7%). control group consisted 50 healthy women men, 52.7±6.4 years equal proportion. was carried out by real-time PCR determination alleles polymorphisms AGT 521 C>T, 704 T>C. Results Patients crisis were characterized LV hypertrophy, thickening intima-media thickness common carotid artery, kidney damage. Henken's test showed that AH require a significantly higher concentration table salt to determine threshold taste sensitivity than group: 0.51±0.17% versus 0.21±0.14% NaCl. distribution 704T>C polymorphism as follows: CC genotype 43.6%, CT 45.8%, TT 10.6% cases, χ2=32.777, p=0.000; C allele – 66.5%, T - 33.5% χ2=40.894, p=0.000. Among individuals, significant predominance genotype: 76%, 24%, not detected presented sample, χ2=67.92, C-allele 88%, T-allele 12%, χ2=115.52, above data people corresponded theoretical Hardy-Weinberg equilibrium. 521T>C among 79.8%, 16%, 4.2% χ2=139.8, 87.8%, 12.2%, χ2=214.5, shown: 40%, 60% χ2=42.0, 70%, 30%, χ2=32.0, did correspond equilibrium Conclusion living aral sea region, are severe damage target organs, high salt. Based on models inheritance, T>C individuals revealed, which characterizes protective against region. Significantly greater accumulation C>T is factor predisposition complicated Funding Acknowledgement Type funding sources: None.